How can this USB connection be direction-dependent?

A USB connection can be direction-dependent because it has different pins for transmitting and receiving data, and if those pins are not aligned properly, the connection will not work.

Related articles:

How Can This USB Connection be Direction-Dependent?
USB, or Universal Serial Bus, is an industry standard that defines the cables, connectors, and protocols used for communication between devices. One intriguing aspect of USB is that the connection between two devices can be direction-dependent, meaning that the orientation of the connector matters.